Validity of Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio in Diagnosing Early-onset Neonatal Sepsis in Full-term Newborns

Background: This study aimed to evaluate the neutrophil lymphocyte ratio (NLR) and platelet (PLR) as diagnostic adjunct tests for early-onset neonatal sepsis (EOS). Methods: prospective cross-sectional included 80 full-term neonates with confirmed EOS healthy newborns. All examinations were done 24 hours after birth. Neonatal (NS) was characterized a positive blood culture symptoms of infection. Positive indicators, including I/T > 0.2, total leukocytes [WBCs] either 5109/L or 15109/L, thrombocytopenia [150,000/mm3], CRP 1 mg/dL, procalcitonin >0.5 ng/mL considered NS. Results: As predictors EOS, sensitivity NLR PLR 67% 70%, their specificity 99% 73%, respectively. Also, predictive value (PPV) 98% 72%, We found weak correlation between platelets sepsis, Strong WBCs moderate among immature counts (I/T ratio), all which significant. Besides, concerning we an inverse lymphocytes sepsis. Conclusions: are important markers (PPV respectively). Moreover, leukocytosis, thrombocytopenia, high c-reactive protein (CRP), procalcitonin, correlated risk showed more than procalcitonin.